Epstein-Barr virus-specific leukocyte migration inhibition reaction with tumor biopsy extracts: correlation with the presence of viral DNA.
نویسندگان
چکیده
The Epstein-Barr virus (EBV)-specific leukocyte migration inhibition (LMI) reaction was used to detect EBV antigens in human tumor biopsies in parallel with nuclei acid hybridization for EBV DNA. None of six EBV DNA-negative tumors gave any significant LMI reaction. Fourteen of 17 EBV DNA-positive tumors gave a significant difference between the migration of leukocytes from EBV-seropositive versus -seronegative donors. One tumor gave a borderline reaction. The two-LMI-negatives in this group had only a marginal EBV DNA content. It is suggested that the EBV-specific LMI test may be useful for detecting EBV genomes in tissue and tumor extracts.
منابع مشابه
Presence of Viral DNA Reaction with Tumor Biopsy Extracts: Correlation with the Epstein-Barr Virus-specific Leukocyte Migration Inhibition
The Epstein-Barr virus (EBV)-specific leukocyte migration in hibition (LMI) reaction was used to detect EBV antigens in human tumor biopsies in parallel with nucleic acid hybridization for EBV DNA. None of six EBV DNA-negative tumors gave any significant LMI reaction. Fourteen of 17 EBV DMA-positive tumors gave a significant difference between the migration of leukocytes from EBV-seropositive v...
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ورودعنوان ژورنال:
- Cancer research
دوره 43 5 شماره
صفحات -
تاریخ انتشار 1983